It would be extremely useful to be able to configure inbox notifications in the same way email notifications can be configured. One of the reasons we moved to Wrike (which is also reinforced in Wrike's marketing) is that we want to host all of our projects/tasks/to-dos in one place rather than having them spread out in multiple places.
Right now, Wrike is not living up to that promise because much of the important updates that we'd like to know about flow through email, which is outside of Wrike, and there is no option to change this.
For example, I'd like to get notifications in Wrike when data/assignee/status is changed on tasks, someone comments without @mentioning me (on a task I follow), task is deleted, etc.. All of these are available for email, but email notifications suck and there isn't an option to have them natively within Wrike.
This isn't as high priority, but along with configurable notifications within Wrike, it would be great to be able to set default notification settings for new users to Wrike, so I don't have to tell each person individually how to initially set up their preferences.